Altered Bowel Function and Duodenal Bacterial Overgrowth in Patients Treated with Omeprazole (PPI); Lewis SJ, et al, Aliment Pharmacol Ther, Aug 1996; 10(4):557-561
Overuse of proton pump inhibitors; Naunton M, et al, J Clin Phrm Ther, Oct 2000, 25 (5), 333-340
Overuse of acid suppressive therapy in hospitalized patients; Nardino RJ, et al, Am J Gastro, Nov 2000, 95 (11), 3118Ð3122
Double gastric infection with Helicobacter pylori and non- Helicobacter pylori bacteria during acid-suppressive therapy: increase of pro-inflammatory cytokines and development of atrophic gastritis; Sanduleanu S, Jonkers D, et al. Aliment Pharmacol Ther, Aug 2001; 15(8):1163-75
Proton pump inhibitors as a risk factor for Clostridium difficile diarrhea; Cunningham R, et al, J Hosp Infect, Jul 2003,54(3):243-5
Risk of Clostridium difficile diarrhea among hospital inpatients prescribed proton pump inhibitors: cohort and case-control studies; Dial S, Alrasadi K, et al, CMAJ, Jul 2004,171(1):33-8
The Effect of H2-receptor antagonist and proton pump inhibitor on microbial proliferation in the stomach; Wang K, Lin HJ, et al, Hepatogastroenterology, Sep-Oct 2004, 51(59):1540-3
Gastric Juice: A Barrier Against Infectious Disease; Martinsen T, et al, Basic & Clinical Pharmacology & Toxicology, 2005, 96 (2), 94Ð102
Albumin, length of stay, and proton pump inhibitors: key factors in Clostridium difficile-associated disease in nursing home patients; Al-Tureihi FI, et al, J Am Med Dir Assoc, Mar-Apr 2005, 96(2):105-8
Use of Gastric Acid-Suppressive Agents and the Risk of Community-Acquired Clostridum difficile-Associated Disease; Dial S, Delaney JAC, et al, JAMA, Dec 21, 2005, Vol 294, No. 23
Suppression of gastric acid production by proton pump inhibitor treatment facilitates colonization of the large intestine by vancomycin-resistant Enterococcus and Klebsiella pneumoniae in clindamycin-treated mice; Stiefel U, Jump L.P. and Donskey C.J. (Abstract B-1123), 46th Interscience Conference on Antimicrobial Agents and Chemotherapy, Sept. 27-30, 2006, San Francisco
Proton pump inhibitor use and risk of community acquired Clostridium difficile-associated disease defined by prescription for oral vancomycin therapy; Dial S, Delaney JAC, et al, CMAJ, Sept. 26, 2006, 175(7), 745-48
Proton pump inhibitors and the risk of Clostridium difficile-associated disease: further evidence from the community; Cunningham R. CMA, Sept. 26, 2006, 175(7), 757-58
Therapy with gastric acidity inhibitors increase the risk of acute gastroenteritis and community-acquired pneumonia in children; Canani RB, et al, Pediatrics, May 2006, 117 (5):e817-20
Association of H2-blocker therapy and higher incidence of necrotizing enterocolitis in Very Low Birth Weight Infants; Guillet R, Stoll B, et al, Pediatrics, 2006, 117:e137-e142 (doi:10.1542/peds.2005-1543)
Association of H2-blocker therapy and higher incidence of necrotizing enterocolitis: a case of excessive collateral damage?; Patole S, Pediatrics, 2006;117:531-532 (doi:10.1542/peds.2005-2230)
Proton Pump Inhibitor Use by Hospital Inpatients as a Risk for Nosocomial Infection by Clostridum Difficile
; Dasgupta R. MMJ, Vol.III, No. 3, July 2006
Proton pump inhibitor therapy is a risk factor for Clostridium-difficile-associated diarrhea; Yearsley KA, et al, Aliment Pharmacol Ther, Aug 15, 2006, 24(4):613-19
Consequences of Long-Term Proton Pump Blockade: Insights from Studies of Patients with Gastrinomas; Jensen R T, Basic & Clinical Pharmacology & Toxicology. 2006, 98 (1), 4Ð19
Popular Press - News releases:
Reflux Drugs Linked to Rise of Community-Acquired C. Difficile. MedPage Today, Dec 20, 2005.
Heartburn Drugs Cause Diarrhea?; CBS News, Dec 20, 2005
Common Reflux Treatment Linked to Life Threatening Bowel Infection in Premature Infants; NIH News, Feb 8, 2006. http://www.nichd.nih.gov/news/releases/ common reflux.cfm
H2 Blockers in Preemies Raise Necrotizing Enterocolitis Risk; Article review from www.medpage;Today - Feb 9, 2006
Flora Horror: Hospitals Struggle with a Serious New Gut Microbe; Science News, Feb. 18, 2006, 169:7
Prescribing: Stressing appropriate stress ulcer prophylaxis; Shands,Univ, of Florida Drug & Therapy Bulletin, March 2006
Do Acid Blockers Let Microbes Reach the Colon?; Science News, Oct 21, 2006;170: 269
Heartburn drugs are blamed for superbug that kills thousands; Daily Mail, March 13, 2007
